The influence of adrenal dysfunction upon pigmentation and ageing process gives a typical external aspect to Sepia patient. Rigid fibre, shallow complexion, yellow freckles, loss of hair, early graying and premature aging.

      The symptoms of hypoadrenalism are the adynamia, indifference, indolence and melancholic depression which spring from vital exhaustion and tiredness in sepia.
In hypoadrenalism the general muscular tonus is reduced, thus beginning about a constitutional hypotension and generalized ptosis (worse standing, lifting, involuntary urination upon coughing, low backache, prolapse)

      The hyperfunctions of the adrenals with its heterosexual tendency combines with the disorder of the sex sphere, which is the expression of the antifemine attitude. Thus Sepia patients are often masculine women with narrow pelvis, overgrowth of body hair, tendency to beard, mustache and deep voice.As the negation to the role of the women extends itself to include the refusal of the role of mother, we find homosexuality, sexual frigidity, aversion to the opposite sex and to husband and children.

      The wide range of genital disorders include almost every and any disturbance of menstruation, co-habitation, pregnancy and childbirth.The state of general stasis makes itself felt in a slowing down of the abdominal venous circulation. We find abdominal plethora with portal and pelvic congestion resulting into tendency of haemorroids, varicose veins and dyspeptic disorders with a hypersensitivity to fat and intolerance to the pressure of clothes (waist). The systemic effects of hepatic stasis are rheumatic and gouty disorders with thick offensive urine, increased specific gravity with adherent red sediment (phosphates and uric acid).

      As much as the pull of gravity increases the venous engorgement, standing aggravates while lying down gives relief. Since exercise stimulates the circulation while rest encourage stasis, hence we see in sepia opposite modalities of better from vigorous exercises, worse during and after sleep, worse from rest. The general venous stasis with incomplete oxidation and elimination. Insufficiency metabolic compensatory heat production is expressed as desire for fresh air and lack of vital heat.Disturbed skin function leads to increased perspiration.

      Respiratory symptoms : Due to stasis, congestion occurs in the lungs leading to pleuritis, cough comes from stomach with egg like taste, worse in the evening and during rest, better by vigorous exercise.

With Phosphorous the light carrier, sepia has

• Aggravation in afternoon and before thunderstorm
• Better amelioration from eating, cold drinks
• Fear of being alone
• Tendency to anemia
• Lack of stamina
• Affinity to left side